The current research activities of DTMP are focused on the improvement of diagnosis, prophylaxis and treatment of nerve agents or blistering agents exposure. 

Two original prophylactic means (Panpal and Transant) were developed against nerve agents and introduced into the Czech Armed Forces. Panpal is mixed prophylactic antidote administered per os, whose effect is based on the protection of acetylcholinesterase (AChE) against nerve agents and also on the protection of peripheral and central muscarinic receptors. Transant is based on transdermal application of AChE reactivator asoxime (HI-6) prior to nerve agent intoxication. If both prophylactic means (Panpal and Transant) are administered at the same time, their prophylactic effects are potentiated and they represent one of the most powerful prophylaxes used worldwide against nerve agents. 

In addition, the new approach of prophylaxis against nerve agents based on administration of stoichiometric (e.g. recombinant butyrylcholinesterase) or catalytic (e.g. paraoxonase, carboxylesterase, phosphotriesterase) bioscavengers is also studied in DTMP in the collaboration with US research institutions (USAMRICD) and French research institution (CRSSA). 

The research and development of reactivators against nerve agent or organophosphorus pesticide inhibited AChE is other important topic solved in DTOX. The developmental process consists of prediction and design of novel compounds (artificial neuronal networks, molecular modelling), synthesis of novel compounds, reactivation evaluation in vitro and in vivo (reactivating, therapeutic and neuroprotective effects) and receptor studies (muscarinic and nicotinic receptors). The most promising compounds are further recommended for further pre-clinical studies. 

Based on Gulf War Syndrome, the research activities have been also focused on the study of low level nerve agents effects after inhalation exposure. It was demonstrated that even low doses causing latent intoxication may cause various neurobehavioral or biochemical effects that are observed during weeks and months after exposure. 

DTMP is also interested in the studying of blistering agents cellular and molecular mechanism, especially sulphur mustard acute toxicity. The potential antidote against sulphur mustard toxicity is aim of further research. 

Some recent research activities are concerned about reversible AChE inhibitors with implications to prophylaxis against nerve agents or neurodegenerative diseases (e.g. Alzheimer’s disease, Myasthenia gravis).